| 摘要 |
<p>The present invention pro vides novel quinolinyl epoxy ketones and their derivatives of general formula (1) by Darzens reaction of 2-chloroquinoline-3-carbaldehydes and its 6-substituted derivatives of the general formula (5) with phenacyl bromides and its 2- and 4- mono and 2,4-disubstituted derivatives of the general formula (6) in a very mild base at room temperature in a higher chemical purity, greater yield, mild conditions in shorter reaction time and in an efficient eco friendly manner. The required 2-chloroquinoline-3-carbaldehydes and its 6-substituted derivatives of the general formula (5) were prepared from acetanilide and its 4-substituted derivatives using Vilsmeier-Haack procedure. The compounds prepared according to the present invention are useful pharmaceutical producís and intermediates in the preparation of pharmaceutical products. Wherein, R = Hydrogen or Alkyl Group or Alkoxy Group or.Halogen Group R¡ = Hydrogen or Alkyl Group or Alkoxy Group or Halogen Group R2 = Hydrogen or Alkyl Group or Alkoxy Group or Halogen Group</p> |
