TARGETED MOLECULAR IMAGING PROBE AND METHOD FOR IN VIVO MOLECULAR IMAGING

摘要

Disclosed is a targeted molecular imaging probe consisting of a signal component, a component with a targeted affinity to Cx43 and a linker. The biochemical variation characteristic of connexin43 (Cx43) associated with cardiovascular diseases (especially arrhythmia) and neoplastic diseases can be reflected in the form of an image by using the targeted molecular imaging probe capable of being detected by an imaging device, to achieve in vivo molecular imaging.

主权项

1. A process for in vivo molecular imaging, comprising:providing a Cx43 targeted molecular probe consisting of three components:
a signaling component, a Cx43 targeted affinity component and a linker, wherein the signaling component is a moiety which is detectable by an imaging device, the Cx43 targeted affinity component is a polypeptide moiety which specifically binds to Cx43, and the linker links the signaling component to the targeted affinity component; andcarrying out optical imaging, positron emission tomography, single photon emission tomography, magnetic resonance imaging, photoacoustic imaging, ultrasonic imaging or other integrated imaging techniques for in vivo imaging preferably PET/CT or PET/MRI, to the site to be detected in a patient by using the Cx43 targeted molecular probe.