TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF

摘要

The present invention relates to compounds of the following general formula (I):;wherein:
R1 is notably a group —NRaRb, Ra and Rb forming together with the nitrogen atom onto which they are bound, a heterocycle comprising from 5 to 30 atoms,R2 is notably an aryl comprising from 5 to 30 atoms, andR3 is notably an alkenyl comprising from 1 to 20 carbon atoms.

主权项

1. A compound of the following general formula (I): wherein:
R1 is selected from the group consisting of:
(hetero)aryls comprising from 5 to 30 atoms, optionally substituted, andgroups —NRaRb, Ra and Rb forming together with the nitrogen atom to which they are bound, a heterocycle comprising from 5 to 30 atoms, optionally comprising an SO2 radical or another heteroatom selected from the group consisting of N, O and S, said heterocycle being optionally substituted;R2 is selected from the group consisting of:
halogen atoms selected from the group consisting of F, Br and I,aryls comprising from 5 to 30 carbon atoms, optionally substituted,groups —NR′aR′b, R′a and R′b forming together with the nitrogen atom to which they are bound, a heterocycle comprising from 5 to 30 atoms, optionally comprising an SO2 radical or another heteroatom selected from the group consisting of N, O and S, said heterocycle being optionally substituted; andR3 is selected from the group consisting of:
halogen atoms selected from the group consisting of F, Cl and I,alkenyls comprising from 1 to 20 carbon atoms, optionally substituted,groups —C(O)Rc, Rc being selected from the group consisting of a hydrogen atom and an alkyl group comprising from 1 to 10 carbon atoms, said alkyl group being optionally substituted,groups —C(O)OR′c, R′c being selected from the group consisting of a hydrogen atom and an alkyl group comprising from 1 to 10 carbon atoms, said alkyl group being optionally substituted,groups —C(Re)═N—(ORd), Rd and Re being selected independently from the group consisting of a hydrogen atom and an alkyl group comprising from 1 to 10 carbon atoms,heterocycloalkyls comprising from 3 to 20 atoms, optionally substituted,alkyls, comprising from 1 to 20 carbon atoms, optionally substituted with at least one substituent; provided that at least one of R1 and R2 represents a group —NRaRb or a group —NR′aR′b, respectively, as well as its pharmaceutically acceptable salts, its hydrates or its polymorphic crystalline structures, its racemates, diastereoisomers or enantiomers.