发明名称 |
Methods and Microorganisms for the Biological Synthesis of (S) -2-amino-6-hydroxypimelate, Hexamethylenediamine and 6-aminocaproate |
摘要 |
A chemical having the formula (S) 2-amino-6-hydroxypimelate. (S)-2-amino-6-hydroxypimelate can be made using a method comprising culturing a cell comprising an exogenous nucleic acid sequence encoding an enzyme that catalyzes the substrate to product conversion of (S)-2-amino-6-oxopimelate to (S)-2-amino-6-hydroxypimelate and separating the (S)-2-amino-6-hydroxypimelate. The cell may be a recombinant microorganism for producing aminocaproic acid or hexamethylenediamine from (S)-2-amino-6-hydroxypimelate comprising at least one exogenous nucleic acid sequence that expresses at least one polypeptide with substrate preference for homolysine, and amino acid decarboxylase with substrate preference for alpha-aminopimelate. |
申请公布号 |
US2015203879(A1) |
申请公布日期 |
2015.07.23 |
申请号 |
US201314419310 |
申请日期 |
2013.08.21 |
申请人 |
BioAmber Inc. |
发明人 |
Lau Man Kit |
分类号 |
C12P13/00;C12N9/04;C12N9/88;C12N9/06;C12N9/02;C12N9/00;C12N9/16;C12P13/04;C12N9/10 |
主分类号 |
C12P13/00 |
代理机构 |
|
代理人 |
|
主权项 |
1. (canceled) |
地址 |
Plymouth MN US |