发明名称 |
FGFR1 EXTRACELLULAR DOMAIN COMBINATION THERAPIES |
摘要 |
Methods of treating cancer comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule in combination with at least one additional therapeutic agent selected from docetaxel, paclitaxel, vincristine, carboplatin, cisplatin, oxaliplatin, doxorubicin, 5-fluorouracil (5-FU), leucovorin, pemetrexed, and bevacizumab are provided. Dosage packs comprising an FGFR1 ECD and/or an FGFR1 ECD fusion molecule and/or at least one additional therapeutic agent selected from docetaxel, paclitaxel, vincristine, carboplatin, cisplatin, oxaliplatin, doxorubicin, 5-fluorouracil (5-FU), leucovorin, pemetrexed, and bevacizumab are also provided. In some embodiments, a dosage pack comprises instructions for administering FGFR1 ECD and/or FGFR1 ECD fusion molecule with at least one additional therapeutic agent. |
申请公布号 |
US2015203566(A1) |
申请公布日期 |
2015.07.23 |
申请号 |
US201414577330 |
申请日期 |
2014.12.19 |
申请人 |
Five Prime Therapeutics, Inc. |
发明人 |
Long Li;Brennan Thomas |
分类号 |
C07K14/71;A61K31/337;A61K33/24;A61K31/365;A61K31/513;A61K31/282;A61K39/395;A61K31/704;A61K38/17;A61K31/519 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating cancer in a subject comprising administering to the subject an effective amount of a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) fusion molecule and at least one additional therapeutic agent selected from paclitaxel, carboplatin, cisplatin, oxaliplatin, doxorubicin, 5-fluorouracil (5-FU), leucovorin, pemetrexed, etoposide, a VEGF antagonist, a VEGF trap, an anti-VEGF antibody, and bevacizumab, wherein the FGFR1 ECD fusion molecule comprises an FGFR1 ECD comprising an amino acid sequence selected from SEQ ID NOs: 1 to 4 and a fusion partner, wherein administration of the FGFR1 ECD fusion molecule and the at least one additional therapeutic agent results in at least additive inhibition of tumor growth in a mouse zenograft model of the cancer. |
地址 |
South San Francisco CA US |