发明名称 |
PROCESS FOR PURIFICATION OF EPA (EICOSAPENTANOIC ACID) ETHYL ESTER FROM FISH OIL |
摘要 |
<p>Disclosed is a process for extracting and purifying EPA (Eicosapentanoic acid) ethyl ester from a crude fish oil feedstock using a combination of novel esterification and simulated moving bed (SMB) techniques. Crude fish oil diluted in non-polar solvent is esterified with an acid and then transesterified with a base. Following washing, the non-polar phase is directly passed to an SMB zone, comprising a normal phase separation with hydrophilic stationary phase agent and non-polar/organic polar mobile phase desorbent to provide an enhanced omega-3 product, comprising EPA. In a further embodiment, the enhanced omega-3 product is passed to a second and third SMB zones operating in reverse phase using a hydrophobic stationary phase and a polar mobile phase desorbent. The process is useful for producing high purity EPA at purities in excess of 97 wt-% which are not economically recoverable by conventional distillation methods combined with conventional SMB configurations.</p> |
申请公布号 |
WO2015109111(A1) |
申请公布日期 |
2015.07.23 |
申请号 |
WO2015US11638 |
申请日期 |
2015.01.15 |
申请人 |
OROCHEM TECHNOLOGIES, INC. |
发明人 |
OROSKAR, ANIL R.;GOPAL, KRISHNA NAGARAJAN |
分类号 |
A61K31/202;A61K31/20;A61P9/00;A61P9/04 |
主分类号 |
A61K31/202 |
代理机构 |
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代理人 |
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地址 |
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