<p>A TPMS setting tool includes a housing (10) carrying a display unit (11) and an input device (12) on the outside and a circuit board and a power supply device (20) on the inside, the power supply device and the circuit board being electrically coupled together to provide the TPMS setting tool with the necessary working power supply. The housing has a receptacle (13) provided at one side thereof and a connection port (26) with multiple pins mounted inside the receptacle (13) for the connection of a TPMS, enabling the desired communication protocol and ID code to be written into the inserted TPMS.</p>