发明名称 |
PROTEASE-BASED BIOSENSOR MOLECULE |
摘要 |
A biosensor molecule comprises: a protease amino acid sequence; at least one sensor comprising at least one sensor amino acid sequence which is responsive to at least one target molecule; and an inhibitor of the protease activity of said protease amino acid sequence; wherein the biosensor is switchable from a protease active to a protease inactive state, or from a protease inactive to a protease active state when said sensor responds to said target molecule. The biosensor protease may be a protease of a virus such as a Potyvirus or a Flavivirus wherein the inhibitor is an autoinhibitory peptide derived from the virus. The biosensor may respond to the target molecule allosterically or may be cleaved by a target protease molecule. |
申请公布号 |
EP2895859(A1) |
申请公布日期 |
2015.07.22 |
申请号 |
EP20130837496 |
申请日期 |
2013.09.12 |
申请人 |
THE UNIVERSITY OF QUEENSLAND |
发明人 |
ALEXANDROV, Kirill;STEIN, Viktor;TRAU, Matt |
分类号 |
G01N33/542;C07K16/30;C07K16/36;C07K19/00;C12N9/48;C12N9/50;C12N11/18;C12N15/57;C12N15/62;C12Q1/37;G01N33/532;G01N33/543;G01N33/573 |
主分类号 |
G01N33/542 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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