Method for industrially producing (<i>S</i>)-1,1,1-trifluoro-2-propanol

摘要

Disclosed is a method for producing (S)-1,1,1-trifluoro-2-propanol with high optical purity and high yield by having at least one kind of microorganism, which is selected from the group consisting of Hansenula polymorpha, Pichia anomala, Candida parapsilosis, Candida mycoderma, Pichia naganishii, Candida saitoana, Cryptococcus curvatus, Saturnospora dispora, Saccharomyces bayanus and Pichia membranaefaciens, act on 1,1,1-trifluoroacetone. Since microorganisms found in nature are made to act in a natural state, the problems to be raised when a transformant or the like is used can be avoided in this method. Consequently, the method can be easily put in industrial practice.

主权项

1. A method for producing (S)-1,1,1-trifluoro-2-propanol represented by the formula [2],the method comprising the steps of:
reacting a microorganism with 1,1,1-trifluoroacetone represented by the formula [1], the microorganism being found in nature and used in a natural state,wherein at least one kind of microorganism, which is selected from the group consisting of Hansenula polymorpha, Pichia anomala, Candida parapsilosis, Candida mycoderma, Pichia naganishii, Candida saitoana, Cryptococcus curvatus, Saturnospora dispora, Saccharomyces bayanus and Pichia membranaefaciens, is used as the microorganism, by preparing a suspension of the microorganism having a density between 107 and 1011 cfu/ml and adding 1,1,1-trifluoroacetone to the suspension so that the 1,1,1-trifluoroacetone has a concentration between 0.05 and 3% (w/v).