发明名称 |
Therapeutic uses of glutathione mimics |
摘要 |
A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue. |
申请公布号 |
US9084803(B2) |
申请公布日期 |
2015.07.21 |
申请号 |
US200812163192 |
申请日期 |
2008.06.27 |
申请人 |
Board of Trustees of Northern Illinois University |
发明人 |
Gaillard Elizabeth R.;Dillon James P. |
分类号 |
A01N57/00;A61K31/66;A61K31/661 |
主分类号 |
A01N57/00 |
代理机构 |
Barnes & Thornburg LLP |
代理人 |
Barnes & Thornburg LLP ;Martin Alice O. |
主权项 |
1. A prodrug comprisingor esters thereof. |
地址 |
DeKalb IL US |