| 发明名称 |
CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION |
| 摘要 |
This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents. |
| 申请公布号 |
US2015196655(A1) |
申请公布日期 |
2015.07.16 |
| 申请号 |
US201314420189 |
申请日期 |
2013.08.06 |
| 申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
Nair Jayaprakash K.;Kelin Alexander V.;Kandasamy Pachamuthu;Rajeev Kallanthottahill G.;Manoharan Muthiah |
| 分类号 |
A61K47/48;C12N15/113;C07C231/14;C07H15/26;A61K31/7088;C07D207/12 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of formula (A)wherein
each occurrence of X is hydrogen or a hydroxy protecting group; each occurrence of Y is an amine protecting group; n is 0-20; each occurrence of q, r and s is independently 1-7; L is a linking group; and R1 is an iRNA agent;wherein the compound of formula (A) is free or substantially free of one or more of
(i) metal impurities, (ii) each of the following two urea side productsand
(iii) each of the following saccharide compounds |
| 地址 |
Cambridge MA US |
