ECM Constructs for Treating Damaged Biological Tissue

摘要

Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.

主权项

1. An extracellular matrix (ECM) construct for tissue repair, comprising:
a biodegradable support scaffold; and a biodegradable microneedle anchoring member having a top and bottom surface, said microneedle anchoring member including a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein, said support scaffold and anchoring member comprising acellular small intestine submucosa (SIS).