| 发明名称 |
REGULATING ORNITHINE METABOLISM TO MANIPULATE THE HIGH MANNOSE GLYCOFORM CONTENT OF RECOMBINANT PROTEINS |
| 摘要 |
The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture. |
| 申请公布号 |
WO2015105609(A1) |
申请公布日期 |
2015.07.16 |
| 申请号 |
WO2014US69378 |
申请日期 |
2014.12.09 |
| 申请人 |
AMGEN INC. |
发明人 |
KANG, SOHYE;HUANG, CHUNG-JR;BARKHORDARIAN, HEDIEH;BONDARENKO, PAVEL;ZHANG, ZHONGQI |
| 分类号 |
C12P21/00;C07K16/00;C12N1/38;C12N5/00 |
主分类号 |
C12P21/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
