| 主权项 |
1. A composition of matter suitable for use in preventing or treating allergy to birch pollen, said composition being selected from the group consisting of:
a) a composition comprising:
i) at least one of the polypeptides of SEQ ID NO: 74 (BIR12B; AKYMVIQGEPGRVIRGK), SEQ ID NO: 72 (BIR11; FPQFKPQEITGIMK), SEQ ID NO: 71 (BIR10; GSVWAQSSSFPQFK), SEQ ID NO: 73 (BIR12A; PTGMFVAGAKYMVIQGR), SEQ ID NO: 75 (BIR13; IKYMVIQGEAGAVIRGK) and SEQ ID NO: 76 (BIR14; EAGAVIRGKKGSGGIT), or a variant of any thereof, andii) at least one of the polypeptides of SEQ ID NO: 53 (Bir02J; PAARMFKAFILEGDKLVPK), SEQ ID NO: 48 (Bir01I; FNYETETTSVIPAARK), SEQ ID NO: 54 (Bir04; PGTIKKISFPEGFPFKYV), SEQ ID NO: 67 (Bir09; ETLLRAVESYLLAHSDAY), SEQ ID NO: 60 (BIR07; SNEIKIVATPDGGSILK), and SEQ ID NO: 63 (Bir07C; SNEIKIVATPEGGSILK), or a variant of any thereof, wherein a variant of a polypeptide is:
I) up to 30 amino acids in length and comprises the sequence of the said polypeptide, orII) 9 to 30 amino acids in length and comprises a sequence that has at least 65% homology to the sequence of said polypeptide, which sequence is capable of tolerising to said polypeptide; orIII) 9 to 30 amino acids in length and comprises a sequence of at least 9 contiguous amino acids of the sequence of said polypeptide, or a sequence that has at least 65% homology to said at least 9 contiguous amino acids, which sequence of at least 9 contiguous amino acids or homologous sequence is capable of tolerising to said polypeptide; b) a composition comprising at least one polynucleotide sequence which when expressed causes the production of a composition as defined in (i); c) a vector comprising four or more polynucleotide sequences which each encode a different polypeptide as defined in (i); d) a product comprising:
i) at least one of the polypeptides of SEQ ID NO: 74 (BIR12B; AKYMVIQGEPGRVIRGK), SEQ ID NO: 72 (BIR11; FPQFKPQEITGIMK), SEQ ID NO: 71 (BIR10; GSVWAQSSSFPQFK), SEQ ID NO: 73 (BIR12A; PTGMFVAGAKYMVIQGR), SEQ ID NO: 75 (BIR13; IKYMVIQGEAGAVIRGK) and SEQ ID NO: 76 (BIR14; EAGAVIRGKKGSGGIT), or a variant of any thereof, and ii) at least one of the polypeptides of SEQ ID NO: 53 (Bir02J; PAARMFKAFILEGDKLVPK), SEQ ID NO: 48 (Bir01I; FNYETETTSVIPAARK), SEQ ID NO: 54 (Bir04; PGTIKKISFPEGFPFKYV), SEQ ID NO: 67 (Bir09; ETLLRAVESYLLAHSDAY), SEQ ID NO: 60 (BIR07; SNEIKIVATPDGGSILK), and SEQ ID NO: 63 (Bir07C; SNEIKIVATPEGGSILK), or a variant of any thereof, wherein a variant of a polypeptide is as defined in claim 1(a) (I), (II) or (III), and wherein each different polypeptide is for simultaneous, separate or sequential use in preventing or treating allergy to birch pollen; and e) a pharmaceutical formulation comprising a composition according to (a) or (b); a vector according to (c); or a product according to (d); and a pharmaceutically acceptable carrier or diluent, and optionally one or more adjuvants selected from a glucocorticoid, vitamin D and rapamycin. |
