Disclosed is a pharmaceutical composition for gene delivery, comprising: (i) a gene; (ii) a water-soluble chitosan; (iii) a thiamine pyrophosphate or a pharmaceutically acceptable salt thereof; (iv) a protamine or a pharmaceutically acceptable salt thereof; and (v) a neutral or anionic phospholipid. The composition can introduce a gene into cells safely and effectively. Composed of non-toxic and injectable components, the composition is safe for the body and can be advantageously commercialized. Notably, it can deliver a gene at high efficiency in vivo as well as in vitro, and is stable in the blood.
申请公布号
EP2776056(A4)
申请公布日期
2015.07.15
申请号
EP20120847217
申请日期
2012.11.09
申请人
CHONG KUN DANG PHARMACEUTICAL CORP.
发明人
LEE, YOUNG NAM;HWANG, HO YOUNG;NOH, SANG MYOUNG;CHO, HEE-JEONG;CHAE, AH-REUM;LEE, JI HEE;KI, MIN HYO;LIM, JONG LAE