发明名称 PROMOTER FOR EXPRESSION OF CLOCK GENE AND HYALURONIC ACID SYNTHASE GENE
摘要 To further effectively promote expression of a clock gene and a hyaluronic acid synthase gene in skin. A composition comprising one kind or two kinds selected from lavender oil and eucalyptus oil, and an alkylene oxide derivative represented by general formula (I) is applied onto skin: R 1 O-[(AO) m (EO) n ]-R 2 (I) (wherein, AO represents an oxyalkylene group having 3-4 carbon atoms; EO represents an oxyethylene group; m and n independently represent an average number of moles of the oxyalkylene group having 3-4 carbon atoms added and the oxyethylene group added, respectively, and satisfy expressions: 1 ‰¤ m ‰¤ 70 and 1 ‰¤ n ‰¤ 70, wherein a ratio of the oxyethylene group to a total of the oxyalkylene group and the oxyethylene group is 20-80 mass%. The oxyalkylene group and the oxyethylene group may be added in a block form or random form. R 1 and R 2 may be the same or different, and independently represent a hydrocarbon group having 1-4 carbon atoms or a hydrogen atom, wherein a ratio of number of hydrogen atoms to number of hydrocarbon groups in R 1 and R 2 is 0.15 or less).
申请公布号 EP2762130(A4) 申请公布日期 2015.07.15
申请号 EP20110873013 申请日期 2011.09.29
申请人 SHISEIDO CO., LTD. 发明人 GOZU, YOKO;HAZE, SHINICHIRO
分类号 A61K8/97;A61K8/33;A61K8/86;A61K36/18;A61K36/53;A61K36/61;A61Q19/00 主分类号 A61K8/97
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