Flexible multi-moduled nanoparticle-structured sensor array on polymer substrate and methods for manufacture

摘要

A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.

主权项

1. A flexible chemiresistor module for sensing a molecule of interest, said flexible chemiresistor module comprising:
a flexible substrate; and a thin film nanoparticle assembly disposed on the flexible substrate, said thin film nanoparticle assembly comprising:
metal or metal alloy core, ligand-capped nanoparticles comprising a nanoparticle capping ligand,molecular linkers connecting adjacent ones of the metal or metal alloy core, ligand-capped nanoparticles, the molecular linkers comprising mercaptocarboxylic acid with a carboxyl end forming hydrogen bonds with the metal or metal alloy core, ligand-capped nanoparticles, anda plurality of microelectrodes coupled to one or more of the metal or metal alloy core, ligand-capped nanoparticles, wherein the flexible substrate and the thin film nanoparticle assembly are configured to bend from a first orientation to a second orientation, which is different than the first orientation, wherein the thin film assembly adheres to the flexible substrate via hydrophobic interaction between the flexible substrate and the nanoparticle capping ligand of the ligand-capped nanoparticles, wherein the first orientation is planar and the second orientation configures the substrate and the thin film nanoparticle assembly to conformally adapt to a cylinder of a defined diameter by convex bending and concave bending, and wherein the thin film nanoparticle assembly is configured to maintain chemical sensitivity in response to exposure to the molecule of interest to induce an electrical signal across the plurality of microelectrodes in the second orientation.