| 发明名称 | Concentrated, inhalable antibiotic formulation | ||
| 摘要 | A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions. | ||
| 申请公布号 | US9078897(B1) | 申请公布日期 | 2015.07.14 |
| 申请号 | US201514676367 | 申请日期 | 2015.04.01 |
| 申请人 | ARADIGM CORPORATION | 发明人 | Cipolla David C.;Blanchard James |
| 分类号 | A61K31/496;A61K9/127;A61K9/00 | 主分类号 | A61K31/496 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Bozicevic, Field & Francis LLP ;Bozicevic Karl |
| 主权项 | 1. An aerosolized composition of particles, comprising: a free, unencapsulated ciprofloxacin in an aqueous solution with sodium acetate at a pH of 3.2; and a liposome-encapsulated ciprofloxacin; wherein the composition is formulated for aerosolized delivery to a human lung and particles of the aerosol have a diameter in a range from about 2 microns to about 4 microns; and wherein the free, unencapsulated ciprofloxacin is in the aqueous solution at a concentration of about 10 mg/mL or more. | ||
| 地址 | Hayward CA US | ||