| 发明名称 |
Process for the preparation of substituted pyrimidine derivatives |
| 摘要 |
The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis. |
| 申请公布号 |
US9079884(B2) |
申请公布日期 |
2015.07.14 |
| 申请号 |
US201314076955 |
申请日期 |
2013.11.11 |
| 申请人 |
Janssen Pharmaceutica NV |
发明人 |
Cesco-Cancian Sergio;Chen Hongfeng;Grimm Jeffrey S.;Mani Neelakandha S.;Mapes Christopher M.;Palmer David C.;Pippel Daniel J.;Sorgi Kirk L.;Xiao Tong |
| 分类号 |
C07D401/12;C07D211/22;C07D211/26 |
主分类号 |
C07D401/12 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A compound of formula (XII) wherein PG3 is a nitrogen protecting group selected from the group consisting of: —C(O)O—C(CH3)3, —C(O)—CH3 and —C(O)O—CH2CH3; L1 is CN; Rc is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, —CF3, cyclopropyl, and cyclobutyl; R8 is selected from the group consisting of hydrogen and C1-4alkyl;Z is selected from the group consisting of N and CH;
n is 1 or 2;R9, R10 and R11 are each independently selected from the group consisting of hydrogen and C1-4alkyl;or a pharmaceutically acceptable salts thereof. |
| 地址 |
Beerse BE |
