发明名称 |
Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as Janus kinase inhibitors |
摘要 |
The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases. |
申请公布号 |
US9079912(B2) |
申请公布日期 |
2015.07.14 |
申请号 |
US201414274948 |
申请日期 |
2014.05.12 |
申请人 |
Incyte Corporation |
发明人 |
Rodgers James D.;Shepard Stacey |
分类号 |
A61K31/519;C07D417/04;C07D487/04;C07D471/04;A61K45/06 |
主分类号 |
A61K31/519 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A method of inhibiting JAK1 and/or JAK2 in a patient in need thereof, comprising administering to said patient an effective amount of a compound which is 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, or a pharmaceutically acceptable salt thereof. |
地址 |
Wilmington DE US |