Longevity of hyperpolarized enhanced signals for ¹H NMR spectroscopy

摘要

A method and system for providing an article of manufacture with increased longevity of hyperpolarized 1H signals (and other species) for NMR spectroscopy and MRI. The method involves providing a material including a molecular species susceptible of NMR spectroscopy, by providing parahydrogen (and other appropriate species) to disperse within the material/solvent to establish increased longevity of the NMR signals. The material can be in a solution with a surfactant and catalysts added to enhance the persistence of parahydrogen (or other species) in the form of enhanced solubility, microbubbles or micelles and resultant hydrogenation (or other species) of the material.

主权项

1. A method of providing increased longevity of hyperpolarized 1H NMR signals for NMR spectroscopy and magnetic resonance imaging (MRI), comprising the steps of:
providing a material including a molecular species susceptible of NMR and MRI spectroscopy/imaging; providing parahydrogen for input to the material; and inputting the parahydrogen to the material by distributing parahydrogen through the material for a time to establish increased longevity of the NMR and MRI signals;adding a surfactant to the material, thereby providing increased persistence of the parahydrogen for the molecular species.