SOLID SELF-EMULSIFYING FORMULATION OF TAMOXIFEN IN COMBINATION OF ANTIOXIDANT FOR ENHANCED ORAL BIOAVAILABILITY AND ANTITUMOR EFFICACY

摘要

The present invention provides a novel solid self-emulsifying formulation comprising tamoxifen in combination with antioxidant such as quercetin, a solid carrier, an oily phase, a surfactant and a co-surfactant. The developed formulation showed enhanced oral bioavailability, improved breast tumor efficacy and reduced the hepatotoxicity.