发明名称 |
GLYCOPROTEIN |
摘要 |
The invention relates to a composition comprising a glycoprotein comprising the Fc domain of an antibody, or a fragment thereof, comprising an Asn (asparagine) residue and an oligosaccharide structure attached thereto, wherein said oligosaccharide structure has a structure according to formula I; and wherein at least 20% of the oligosaccharide structures attached to glycoprotein in the composition consist of oligosaccharide structures according to formula (I). |
申请公布号 |
US2015191544(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
US201214365022 |
申请日期 |
2012.12.13 |
申请人 |
Glykos Finland Oy |
发明人 |
Satomaa Tero;Saarinen Juhani;Natunen Jari;Vilkman Anja;Virtanen Heidi;Hiltunen Jukka |
分类号 |
C07K16/28;A61K47/48;C07K16/24 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising a glycoprotein comprising the Fc domain of an antibody, or a fragment thereof, comprising an Asn residue and an oligosaccharide structure attached thereto, wherein the oligosaccharide structure has a structure according to formula Iwherein
(β-N-Asn)=β-N linkage to Asn;
wherein at least 20% of the oligosaccharide structures attached to glycoprotein in the composition consist of oligosaccharide structures according to formula I. |
地址 |
Helsinki FI |