METHODS OF ASSESSING EPIGENETIC REGULATION OF GENOME FUNCTION VIA DNA METHYLATION STATUS AND SYSTEMS AND KITS THEREFOR

摘要

The invention comprises systems, kits and methods for assessing epigenetic regulation of genome function by assessing DNA methylation status. The invention comprises the convert-then-capture method wherein the unmethylated cytosine residues are first converted to uracil residues and the target DNA is then captured for subsequent analysis. The method uses novel capture probe pool for a solution-phase capture.