| 发明名称 |
CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS |
| 摘要 |
The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders. |
| 申请公布号 |
US2015192582(A1) |
申请公布日期 |
2015.07.09 |
| 申请号 |
US201514666772 |
申请日期 |
2015.03.24 |
| 申请人 |
The Regents of the University of California |
发明人 |
Bluestone Jeffrey A.;Liu Weihong;Putnam Amy |
| 分类号 |
G01N33/569;A61K35/17 |
主分类号 |
G01N33/569 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of identifying immunosuppressive regulatory T-cells in a sample, said method comprising:
screening T-cells in said sample to detect CD127lo/− T-cells; and identifying said detected CD127lo/− T-cells as immunosuppressive regulatory T-cells. |
| 地址 |
Oakland CA US |
