Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
申请公布号
EP2588126(A4)
申请公布日期
2015.07.08
申请号
EP20110798640
申请日期
2011.06.14
申请人
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION