发明名称 |
Aromatic ring compound |
摘要 |
Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I):;
wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like. |
申请公布号 |
US9073864(B2) |
申请公布日期 |
2015.07.07 |
申请号 |
US201314389004 |
申请日期 |
2013.03.28 |
申请人 |
Takeda Pharmaceutical Company Limted |
发明人 |
Sasaki Minoru;Furukawa Hideki;Hidaka Kousuke;Toyofuku Kyoko;Yogo Takatoshi;Murata Toshiki |
分类号 |
C07D211/06;A61K31/445;C07D211/60;C07D401/12;C07D401/06;C07D413/12;C07D498/04;C07D405/14 |
主分类号 |
C07D211/06 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. A compound represented by the formula (I): wherein ring A is an optionally further substituted 5- or 6-membered aromatic ring, and the 5- or 6-membered aromatic ring is optionally fused with an optionally substituted 5- to 7-membered ring; ring B is an optionally further substituted 6-membered aromatic ring; R1 is C1-6 alkyl optionally substituted by a halogen atom, or C3-10 cycloalkyl optionally substituted by a halogen atom; R2 is a hydrogen atom, a halogen atom, or C1-6 alkyl optionally substituted by a halogen atom; and X is CH or N, or a salt thereof. |
地址 |
Osaka JP |