发明名称 Aromatic ring compound
摘要 Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I):; wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.
申请公布号 US9073864(B2) 申请公布日期 2015.07.07
申请号 US201314389004 申请日期 2013.03.28
申请人 Takeda Pharmaceutical Company Limted 发明人 Sasaki Minoru;Furukawa Hideki;Hidaka Kousuke;Toyofuku Kyoko;Yogo Takatoshi;Murata Toshiki
分类号 C07D211/06;A61K31/445;C07D211/60;C07D401/12;C07D401/06;C07D413/12;C07D498/04;C07D405/14 主分类号 C07D211/06
代理机构 Wenderoth, Lind & Ponack, L.L.P. 代理人 Wenderoth, Lind & Ponack, L.L.P.
主权项 1. A compound represented by the formula (I): wherein ring A is an optionally further substituted 5- or 6-membered aromatic ring, and the 5- or 6-membered aromatic ring is optionally fused with an optionally substituted 5- to 7-membered ring; ring B is an optionally further substituted 6-membered aromatic ring; R1 is C1-6 alkyl optionally substituted by a halogen atom, or C3-10 cycloalkyl optionally substituted by a halogen atom; R2 is a hydrogen atom, a halogen atom, or C1-6 alkyl optionally substituted by a halogen atom; and X is CH or N, or a salt thereof.
地址 Osaka JP