Natural composition to decrease effects of a high fat diet

摘要

The combination of gallic acid, ellagic acid, and rubusoside was shown to inhibit angiogenesis by inhibition of pro-angiogenic factors. These three compounds were shown to be absorbed from the intestine making the compounds orally bioavailable. The ratio of the three compounds in the composition was a weight ratio of approximately 1:1.7:17.0 of gallic acid, ellagic acid, and rubusoside, respectively, resulting in a composition with 5% w/w gallic acid, 9% w/w ellagic acid, and 86% w/w rubusoside. This combination was also shown to reduce weight gain, fat accumulation, and serum cholesterol in mammals fed a high fat diet. It also reduced serum triglycerides and tended to reduce blood glucose in mammals on both normal and high fat diets. This three-compound composition (“GER”) can be used to treat diseases associated with angiogenesis and to decrease effects of a high fat diet.

主权项

1. A method to decrease symptoms in a mammal on a high fat diet; wherein said decrease in symptoms is selected from the group consisting of decreased weight gain, decreased fat accumulation, decreased serum cholesterol, and decreased serum triglycerides; said method comprising orally administering to the mammal an effective amount of a composition that comprises gallic acid, ellagic acid, and rubusoside in a ratio of about 1:1.7:17; wherein the composition contains no steviol monoside.