发明名称 Modified human plasma polypeptide or Fc scaffolds and their uses
摘要 Modified human plasma polypeptides or Fc and uses thereof are provided.
申请公布号 US9074010(B2) 申请公布日期 2015.07.07
申请号 US201113208136 申请日期 2011.08.11
申请人 Ambrx, Inc. 发明人 Sheffer Joseph;Norman Thea;Dimarchi Richard D.;Hays Putnam Anna-Maria A.;Tian Feng;Chu Stephanie;Krawitz Denise;Cho Ho Sung
分类号 C07K14/765;C07K14/47;A61K38/38;C12N15/14;C07K19/00;A61K38/00 主分类号 C07K14/765
代理机构 代理人 Wallen, III John W.;Eaton Kristin S.
主权项 1. A human serum albumin (HSA) comprising a non-naturally encoded amino acid at one or more of the following positions: 34, 82, 172, 301, 364, and 505 of SEQ ID NO: 1, linked to one or more biologically active molecules selected from the group consisting of relaxin, angiotensin peptides, antibiotic peptides, antigenic polypeptides, anti-microbial peptides, apoptosis related peptides, atrial natriuretic peptides, bag cell peptides, bombesin peptides, bone GLA peptides, bradykinin peptides, brain natriuretic peptides, C-peptides, C-type natriuretic peptides, calcitonin peptides, calcitonin gene related peptides, CART peptides, casomorphin peptides, chemotactic peptides, cholecystokinin peptides, colony-stimulating factor peptides, corticortropin releasing factor peptides, cortistatin peptides, cytokine peptides, dermorphin peptides, dynorphin peptides, endorphin peptides, endothelin peptides, ETa receptor antagonist peptides, or ETb receptor antagonist peptides.
地址 La Jolla CA US