Therapeutic composition with enhanced endothelium targeting

摘要

A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed.

主权项

1. A composition comprising:
a plurality of nanoparticles each comprising a first functional group and a second functional group, wherein:
the first functional group and the second functional group are operatively coupled to a surface of the nanoparticles;the first functional group has binding affinity for platelets, and comprises one or more first peptides or first proteins or any combination thereof;the second functional group has binding affinity for endothelium, and comprises one or more second peptides or second proteins, or any combination thereof; and a bioactive agent encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles, wherein the bioactive agent does not promote clotting or thrombogenesis.