Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core

摘要

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.;

主权项

1. A compound of formula (I): wherein: X is N or C; Y is C or N; wherein when X═N then Y═C and when X═C then Y═N; R1 is aryl or heteroaryl selected from the group consisting of phenyl, isoxazolyl, oxazolyl, imidazolyl, pyrazolyl, thiazolyl, furanyl, thienyl, pyrrolyl, pyridinyl, pyrimidinyl, pyridazinyl, benzimidazolyl, benzopyrazolyl, pyrazolopyridinyl, imidazopyridinyl, indolyl, and quinolinyl; wherein each of the foregoing R1 groups is optionally substituted with 1 to 3 substituents selected from R6; R2 and R3 are each independently H or C1-C5 alkyl; or R2 and R3 together with the carbon atom to which they are attached, form a C3-C8 cycloalkyl ring; R4 and R5 are each independently H or C1-C5 alkyl; or R4 and R5 together with the carbon atom to which they are attached, form a C3-C8 cycloalkyl ring; each R6 is independently C1-C5 alkyl, —C1-C5 alkylamino, —C1-C5 alkyl-NH—C1-C3 alkyl, —C1-C5 alkyl-N(C1-C3 alkyl)2, —C1-C5 alkyl-aryl, —C1-C5 alkyl-heteroaryl, —C1-C5 alkyl-heterocyclyl, C1-C5 alkoxyl, C3-C8 cycloalkyl, —C(O)NH2, —C(O)NH—C1-C5 alkyl, —C(O)N(C1-C5 alky)2, —C(O)NH—C3-C8 cycloalkyl, —C(O)OC1-C5 alkyl, halogen, cyano, heterocyclyl, aryl or heteroaryl; wherein each aryl and heteroaryl of said R6 is optionally independently substituted with 1 to 2 of C1-C5 alkyl; n is 0 or 1; or a pharmaceutically acceptable salt thereof.