Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors

摘要

The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.;

主权项

1. A compound of the formula below:wherein
R1 is selected from: —CH3 and —CF3; R2 is selected from H, —C1-4alkyl, —C3-4cycloalkyl, —C1-2alkylcyclopropyl, —O—C1-2alkyl, phenyl, 2-benzothiazolyl, 2-pyridinyl, and 3-pyridinyl, wherein the phenyl is optionally substituted with 1 or 2 groups independently selected from: halogen, —C1-2alkyl, —CF3, —OC1-3alkyl, and —OC1-2haloalkyl, and the pyridinyl is optionally substituted with 1 or 2 groups independently selected from —CH3, halogen, —OCH2cyclopropyl, and —OC1-3alkyl; and R3 is selected from: H, —OC1-4alkyl, —OC1-3alkyl, —OC1-2haloalkyl, phenyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, and 2-thiazolyl, wherein the phenyl is optionally substituted with a halogen; provided that if one of R2 and R3 is H then the other one of R2 and R3 is not H; or a pharmaceutically acceptable salt thereof.