Perlecan domain V protects, repairs and restores ischemic brain stroke injury and motor function

摘要

The disclosed invention relates to the use of perlecan domain V (DV) for the treatment of stroke, traumatic brain injury (TBI) or spinal cord injuries (SCI). In certain embodiments, fusion proteins of DV can be used for the treatment of stroke, TBI or SCI. DV is also referred to as endorepellin in the art. This application also provides compositions and combination therapies for the treatment of stroke, TCI and/or SCI. Another aspect of the invention provides methods of restoring motor function in subjects having neurological damage arising from a stroke, TBI or SCI.

主权项

1. A method of treating stroke, traumatic brain injury (TBI) or spinal cord injury (SCI) comprising administering to a subject having had a stroke, TBI or SCI a first composition comprising a pharmaceutically acceptable excipient and:
a) perlecan domain V (SEQ ID NO: 1; DV); b) a fusion protein comprising DV; c) a fragment of SEQ ID NO: 1, said fragment:
(i) consisting of SEQ ID NO: 2; or(ii) consisting essentially of SEQ ID NO: 2; or d) a fusion protein comprising a heterologous sequence operably fused to a fragment of SEQ ID NO: 1, said fragment:
(i) consisting of SEQ ID NO: 2; or(ii) consisting essentially of SEQ ID NO: 2; wherein said subject is administered the first composition alone or in combination with a second composition.