SIDE CHAIN PROTECTED OLIGOPEPTIDE FRAGMENT CONDENSATION USING SUBTILISINS IN ORGANIC SOLVENTS

摘要

Method for enzymatically synthesising an oligopeptide comprising the coupling of an (optionally N protected) protected oligopeptide ester with an (optionally C protected) protected oligopeptide nucleophile in an organic solvent or an organic solvent mixture having a water content of 0.1 vol% or less by a subtilisin in any possible form.