METHODS FOR DETERMINING THE PROPENSITY OF A PATIENT FOR HEMORRHAGIC TRANSFORMATION AFTER STROKE
摘要
<p>The invention relates to a method for predicting the risk of suffering symptomatic hemorrhagic transformation in response to the treatment with a thrombolytic agent in an ischemic stroke patient based on the determination of the level of Nurrl in a sample of said patient. Furthermore the invention relates to a composition comprising a Nurrl inhibitor and a thrombolytic agent and to a pharmaceutical preparation comprising the composition of the invention and a pharmaceutically acceptable excipient or carrier. The invention also relates to the use of an inhibitor of Nurrl in the treatment of cytotoxicity associated to the treatment with a thrombolytic agent and to the use of the composition and the pharmaceutical preparation of the invention in the treatment of ischemic stroke.</p>
申请公布号
WO2015097145(A1)
申请公布日期
2015.07.02
申请号
WO2014EP78977
申请日期
2014.12.22
申请人
FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
发明人
MERINO ZAMORANO, CRISTINA;ROSELL NOVEL, ANNA;HERNÁNDEZ GUILLAMÓN, MAR;MONTANER VILALLONGA, JOAN