ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF IN MEDICAL SCIENCE

摘要

Provided in the present invention are an acyclic nucleoside phosphonate derivative and a preparation method and use thereof in medical science, and the acyclic nucleoside phosphonate derivative is a compound as shown by general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof: R1 is H or methyl; R2 is H, C1-10 alkyl, -(CH2-CH2-O)n-H or -(CH2-CH2-O)n-C1-10 alkyl, wherein the alkyl is optionally further substituted by 0 to 5 R2as; R3 is C1-10 alkyl, -(CH2-CH2-O)n-H or -(CH2-CH2-O)n-C1-10 alkyl, wherein the alkyl is optionally further substituted by 0 to 5 R3as; each of R2a and R3a are independently H, F, Cl, Br, I, hydroxyl, sulfydryl, amino, cyano, carboxyl, C1-4 alkyl or C3-6 cycloalkyl; and n is 1-10.