发明名称 |
PHARMACOLOGICALLY ACTIVE COMPOUNDS |
摘要 |
The present invention relates to compounds of formula (I) shown below: wherein Q is as defined herein. The compounds of formula (I) act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them. |
申请公布号 |
CA2933401(A1) |
申请公布日期 |
2015.07.02 |
申请号 |
CA20142933401 |
申请日期 |
2014.12.23 |
申请人 |
THE UNIVERSITY OF LIVERPOOL |
发明人 |
LEUWER, MARTIN;O'NEILL, PAUL;BERRY, NEIL;PIDATHALA, CHANDRAKALA |
分类号 |
C07D205/04;A61K31/397;A61K31/4453;A61K31/4965;A61K31/5375;A61P23/00;C07D265/30;C07D295/192;C07D493/10 |
主分类号 |
C07D205/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|