| 主权项 |
1. A compound of Formula (I)wherein
A denotes a 5- to 7-membered saturated carbocyclic ring wherein 1 —CH2— group is optionally substituted by an oxygen atom R1 and R1′ are each independently selected from halogen, CF3, C1-C6-alkyl optionally substituted with one to 3 Hal, C1-C6-alkoxy, CN, C1-C6-alkyl sulfonyl and amine; Q is selected from a double bond, —NR4—, —(CH2)NR4CO—, —NR4CO—, —CONR4—, and —CONR4—; Z is CH or N, R2 is a 5- to 6-membered unsaturated or aromatic heterocyclic ring containing 1 to 3 heteroatoms independently selected from O, N or S, and which optionally substituted with 1 to 3 groups independently selected from C1-C6-alkyl, and C1-C6 alkoxy, R3 is H, C1-C6-alkoxy, CN, or halogen; and each R4 is independently H or C1-C6-alkyl; and pharmaceutically acceptable derivatives, solvates, tautomers, salts, hydrates and stereoisomers thereof, including mixtures thereof in all ratios. |
