| 发明名称 |
CRYSTALLINE ANTI-HTNFALPHA ANTIBODIES |
| 摘要 |
The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions. |
| 申请公布号 |
US2015183863(A1) |
申请公布日期 |
2015.07.02 |
| 申请号 |
US201414309208 |
申请日期 |
2014.06.19 |
| 申请人 |
ABBVIE BIOTECHNOLOGY LTD. |
发明人 |
Borhani David W.;Fraunhofer Wolfgang;Krause Hans-Juergen;Koenigsdorfer Anette;Winter Gerhard;Gottschalk Stefan |
| 分类号 |
C07K16/24 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A batch crystallization method for crystallizing an anti-hTNFalpha antibody, comprising the steps of:
(a) providing an aqueous solution of said antibody in admixture with an inorganic phosphate salt as crystallization agent; and (b) incubating said aqueous crystallization mixture until crystals of said antibody are formed. |
| 地址 |
Hamilton BM |
