发明名称 |
METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS |
摘要 |
The present disclosure provides methods of delivering a protective ApoE isoform to the central nervous system of a mammal, comprising administering to the cerebrospinal fluid (CSF) of the mammal an rAAV particle comprising an AAV capsid protein and a vector comprising a nucleic acid encoding the protective ApoE isoform inserted between a pair of AAV inverted terminal repeats in a manner effective to infect ependymal cells in the non-rodent mammal such that the ependymal cells secrete the ApoE into the CSF of the mammal. |
申请公布号 |
US2015183850(A1) |
申请公布日期 |
2015.07.02 |
申请号 |
US201314402064 |
申请日期 |
2013.03.14 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION ;THE GENERAL HOSPITAL CORPORATION |
发明人 |
Davidson Beverly L.;Hyman Bradley T. |
分类号 |
C07K14/775;C12N7/00;A61K38/16 |
主分类号 |
C07K14/775 |
代理机构 |
|
代理人 |
|
主权项 |
1. (canceled) |
地址 |
Iowa City IA US |