发明名称 CD44V6-Derived Peptides for Treating Metastasizing Cancer
摘要 The present invention relates to compounds, pharmaceutical compositions and methods for treating different forms of pancreatic cancer.
申请公布号 US2015183826(A1) 申请公布日期 2015.07.02
申请号 US201314407283 申请日期 2013.11.21
申请人 KARLSRUHER INSTITUT FÜR TECHNOLOGIE ;AMCURE GMBH 发明人 Orian-Rousseau Veronique;Matzke Alexandra;Ponta Helmut
分类号 C07K7/06;C07K7/08 主分类号 C07K7/06
代理机构 代理人
主权项 1. A method for inhibiting metastasizing cancer tumor growth in a human being, comprising administering a compound to the human being in need thereof, wherein said compound comprises: a peptide comprising at least the amino acid sequence X1-R-W-H-X5 with X1 being selected from the group comprising A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y and X5 being selected from the group comprising A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y (SEQ ID No.: 1), or a peptidomimetic thereof, ora peptide comprising at least 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 amino acids of amino acid sequence X1-X2-X3-X4-X5-X6-X7-R-W-H-X11-X12-X13-X14, wherein X1, X2, X3, X4, X5, X6, X7, X11, X12, X13, or X14 is selected from the group comprising A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y (SEQ ID No.: 7), and wherein the peptide comprises at least X7-R-W-H-X11 of SEQ ID No.: 7, wherein X7, and X11 is selected from the group comprising A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y, or a peptidomimetic thereof.
地址 Eggenstein-Leopoldshafen DE