| 发明名称 |
METHOD OF TREATING PRURITUS WITH IL-31 MONOCLONAL ANTIBODIES |
| 摘要 |
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the proinflammatory or pro-pruritic effects of IL-31. |
| 申请公布号 |
US2015183868(A1) |
申请公布日期 |
2015.07.02 |
| 申请号 |
US201514645769 |
申请日期 |
2015.03.12 |
| 申请人 |
ZymoGenetics, Inc. ;Merck Serono S/A |
发明人 |
Bondensgaard Kent;Beckmann Roland |
| 分类号 |
C07K16/24 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating pruritus in a mammal comprising administering to the mammal a therapeutically effective amount of a monoclonal antibody that specifically binds to human IL-31, wherein the monoclonal antibody comprises a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO:44, and a light chain variable domain comprising the amino acid sequence of SEQ ID NO:26. |
| 地址 |
Princeton NJ US |
