摘要 |
PROBLEM TO BE SOLVED: To provide a novel positively charged NSAIA prodrug which can be administered percutaneously.SOLUTION: This invention provides a compound of a structure 1, 2a, 2b, 2c, or 2d, wherein a positively charged amino group of the prodrug greatly increases solubility of a drug underwater, bonds to a negative charge of a phosphate head group of a film, and the bond makes the film little unstable, so that the prodrug enters the film. |