DEGLYCOSYLATED HEMAGGLUTININ AND MANUFACTURE THEREOF

摘要

The invention provides a deglycosylated hemagglutinin, wherein the glycosylation site(s) on the stem region is removed. The deglycosylated hemagglutinin may induce neutralizing antibody against influenza virus, and cross-reactive protection against different virus. The invention also provides a method for manufacturing deglycosylated hemagglutinin, comprising aligning two or more hemagglutinin stem sequences of influenza virus, identifying the high conserved N-glycosylation site, and removing the high conserved N-glycosylation site. Thus, the N-glycosylation site cannot be glycosyalted.

主权项

1. A deglycosylated hemagglutinin, comprising:
a HA1 module and a HA2 module, and the HA1 and HA2 is classified into a stem region and a head region, wherein glycosylation sites of the HA1 and HA2 on the stem region are removed.