| 发明名称 |
MODULATION OF APOLIPOPROTEIN (a) EXPRESSION |
| 摘要 |
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided. |
| 申请公布号 |
US2015184156(A1) |
申请公布日期 |
2015.07.02 |
| 申请号 |
US201514656454 |
申请日期 |
2015.03.12 |
| 申请人 |
Isis Pharmaceuticals, Inc. |
发明人 |
Crooke Rosanne M.;Graham Mark J. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting apolipoprotein (a) (apo(a)) expression in an animal comprising administering to the animal a compound comprising a modified oligonucleotide 15-30 linked nucleosides in length targeted to apo(a), wherein expression of apo(a) is reduced by at least 30% in the animal. |
| 地址 |
Carlsbad CA US |
