Quality Control Bioassays For Nutriceutical And Medicinal Products

摘要

Bioassays for detecting the ability of one sample of a food substance, nutritional supplement, therapeutic agent and/or disease preventive agent relative to that of a second sample of such a substance, supplement and/or agent to inhibit, upregulate or otherwise modulate translation initiation, and thereby demonstrate a disease curative and/or preventive effect in a human and/or animal that consumes a such substance, supplement and/or agent or to whom a such substance, supplement and/or agent is administered are provided.

主权项

1. A method for identifying or determining whether a substance has one or more beneficial biological, nutriceutical or medicinal properties comprising the steps of:
providing a first sample including a first mRNA sequence having at least two open reading frames at its 5′ untranslated region (UTR), wherein the first mRNA sequence encodes a first biomarker protein; providing a second sample including a second mRNA sequence having at least two open reading frames at its 5′ UTR, wherein the second mRNA sequence encodes a second biomarker protein; contacting the second sample with the substance; and detecting translation levels of the first and second biomarker proteins, wherein the translation level of the second biomarker protein is greater than the translation level of the first biomarker if the substance has one or more beneficial biological, nutriceutical or medicinal properties.