| 发明名称 |
SELECTIVE HDAC6 INHIBITORS |
| 摘要 |
The present invention provides hydroxamic acids of the formula described herein, that have activity toward inhibiting histone deacetylases, and in particular HDAC6. Also contemplated are pharmaceutical compositions and methods of use of an effective amount of the hydroxamic acid compounds provided, for treating a disease in a subject. In certain embodiments, the subject is afflicted with cancer, neurodegenerative disease, or HIV infection. |
| 申请公布号 |
CA2933907(A1) |
申请公布日期 |
2015.07.02 |
| 申请号 |
CA20142933907 |
申请日期 |
2014.12.23 |
| 申请人 |
MEMORIAL SLOAN-KETTERING CANCER CENTER;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
BRESLOW, RONALD;MARKS, PAUL;MAHENDRAN, ADAICKAPILLAI;YAO, YUANSHAN |
| 分类号 |
C07C259/10;A61K31/167;A61K31/216;A61K31/381;A61P3/00;A61P25/16;A61P25/28;A61P35/00;C07D333/38 |
主分类号 |
C07C259/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
