发明名称 |
A NEW METHOD FOR THE SYNTHESIS OF RASAGILINE |
摘要 |
<p>We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction conditions and reagent selection. Considering the ease, purity and high yields of introducing and removal of the trifluoroacetyl group, this approach is a highly practical and economical way for the synthesis of rasagiline or its pharmaceutically acceptable salts.</p> |
申请公布号 |
EP2663545(B1) |
申请公布日期 |
2015.07.01 |
申请号 |
EP20110712351 |
申请日期 |
2011.01.13 |
申请人 |
NOBEL ILAÇ SANAYII VE TICARET A.S. |
发明人 |
REIS, ÖMER;KOYUNCU, HASAN;ESIRINGU, ILKER;SAHIN, YASEMIN;GULCAN, H., OZAN |
分类号 |
C07C209/62;C07C211/42;C07C233/06 |
主分类号 |
C07C209/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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