Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies

摘要

Provided are methods and compositions for treating inflammatory or autoimmune diseases in a subject comprising blocking the interaction between DR3 and TL1A. The interaction between DR3 and TL1A can be blocked by reducing expression of TL1A. The interaction between DR3 and TL1A can be blocked by administration of anti-DR3 antibodies. The interaction between DR3 and TL1A can be blocked by administration of anti-TL1A antibodies. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft versus host disease or inflammatory bowel disease (IBD).

主权项

1. A monoclonal antibody produced by a murine hybridoma clone selected from the group consisting of the anti-human TL1A clone 1A9 and the anti-human TL1A clone 1C6, that binds specifically to TL1A and blocks the interaction between DR3 and TL1A.