Method for detection of radiation-induced damage to biomaterial using magnetic sensor and magnetic sensor biochip for biodosimetry using the same

摘要

Disclosed is a method for the detection of radiation-induced damage on a biomaterial using a magnetic sensor, and a magnetic sensor biochip for biodosimetry. Designed to utilize a magnetic sensor in detecting damage to biomaterials in vitro, the method and magnetic sensor biochip can accurately determine the degree of damage irrespective of the self-recovery of the organism. Thanks to their high sensitivity, the method and biochip can detect the biomaterial damage by exposure to even a low dose of radiation.

主权项

1. A method for detecting radiation-induced damage of a biomaterial, comprising:
a) obtaining a biosample exposed to radiation; b) conjugating a magnetic nanoparticle with a target biomaterial contained in the biosample; c) coupling the magnetic nanoparticle-conjugated target biomaterial with a linker conjugated to a surface of a magnetic sensor to form a complex; d) exposing the coupled complex to radiation; e) measuring radiation-induced damage to the coupling between the linker and the target biomaterial in an electric signature of the magnetic sensor; and f) comparing the measurement with an electric signal of the magnetic sensor detected in a reference sample unexposed to radiation.